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KMID : 0881720150300010120
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Journal of Food Hygiene and Safety
2015 Volume.30 No. 1 p.120 ~ p.125
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Effect of Repeated MSG Administration on Cognitive Ability and Anxiety of Juvenile Rats
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Lee Hae-Nim
Choo Gang-Sik
Shin Seong-Ah
Park Jung-Joon
Lee Se-Geun
Kim Se-Woon
Kim Hyun-Sun
Lee Song-Hee
Lim Jeong-Min
Kim Hyeong-Jin
Park Young-Seok
Kim Sang-Ki
Park Byung-Kwon
Kim Byeong-Soo
Jung Ji-Youn
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Abstract
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The objective of this study is to investigate the effect of MSG on cognitive function and anxiety by the T-maze and elevated-plus-maze test and repeated oral dose toxicity in SD rat of MSG. The rats were treated with MSG of control group, low group (3 g/kg) and high group (5 g/kg) intragastrically for 4 weeks, respectively. We examined the body weight, the clinical signs, T-maze, Elevated-plus-maze, hematological analysis and serum biochemical analysis, we also observed the histopathological changes of liver, kidney in rats. No significant differences in body weights, biochemical analysis and histopathological observations between control and MSG treatment group were found. In the elevated plus maze (EPM), MSG-treatment group has more open arm visited than controls. MSGtreatment group has been more activated in T-maze test. These data indicate the continuous high MSG intake could be increased the anxiety and could be decreased cognitive ability. In conclusion, MSG is physiologically safety, but high MSG intake could be increased the anxiety and could be decreased cognitive ability in juvenile rat.
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KEYWORD
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Juvenile rats, MSG
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